Cimprich K.A. (2007) Probing ATR activation with model DNA
templates. Cell Cycle [Medline]
Cimprich K.A., Cortez D. (2008) ATR: An essential regulator of
genome integrity. Nat Rev Mol Cell Biol [Medline]
Paulsen, R.D., Cimprich, K.A. (2007) The ATR pathway: Fine-tuning the fork.. DNA Repair [Medline]
MacDougall, C.A., Byun, T.S.,
Van, C., Yee, M.C., Cimprich, K.A. (2007) The structural
determinants of checkpoint activation. Genes Dev 21, 898-903. [Medline]
Lupardus, P.J., Van, C., Cimprich, K.A. (2007) Analyzing the ATR-mediated checkpoint using Xenopus egg extracts. Methods 41(2), 222-231. [Medline]
Chang, D.J., Lupardus, P.J.,
Cimprich, K.A. (2006) Monoubiquitination of PCNA induced by
stalled replication requires uncoupling of DNA polymerase and MCM
helicase activities. J Biol Chem 281(43), 32081-32088. [Medline]
Bomgarden, R.D., Lupardus,
P.J., Soni, D.V., Yee, M.C., Ford, J.M., Cimprich, K.A. (2006)
Opposing effects of the UV lesion repair protein XPA and UV
bypass polymerase eta on ATR checkpoint signaling. EMBO 25(11), 2605-2614. [Medline]
Lupardus, P.J., Cimprich,
K.A. (2006) Phosphorylation of Xenopus Rad1 and Hus1
defines a readout of ATR activation that is independent of Claspin and
the Rad9 carboxy-terminus. Mol Biol Cell, 17(4), 1559-1569. [Medline]
Sobeck, A., Stone, S., Costanzo, V., de Graaf, B., Reuter, T., de
Winter, J., Wallisch, M., Akkari, Y., Olson, S., Wang, W., Joenje, H.,
Christian, J.L., Lupardus, P.J., Cimprich, K.A., Gautier, J., Hoatlin,
M.E. (2006) Fanconi anemia proteins are required to prevent
accumulation of replication-associated DNA double-strand breaks. Mol Cell Biol, 26(2), 425-437. [Medline]
Yee, M-C., Fas, S. C.,
Stohlmeyer, M. M., Wandless, T. J., Cimprich, K. A. (2005)
A cell-permeable activity-based probe for protein and lipid
kinases. J. Biol. Chem., 280, 29053-29059. [Medline]
Byun,
T. S., Pacek, M., Yee,
M-C, Walter, J. C., Cimprich, K. A. (2005) Functional Uncoupling of MCM
Helicase and DNA Polymerase Activities Activates the ATR-Dependent
Checkpoint. Genes Dev, 19, 1040-1052.
[Medline]
O'Connell, M. J. and Cimprich, K. A. (2005)
G2
damage checkpoints: what is the turn-on?. J Cell Sci, 118, 1-6. [Medline]
Lupardus,
P. J. and Cimprich, K. A. (2004)
Checkpoint adaptation: Molecular mechanisms uncovered. Cell,
117, 556-557. [Medline]
Bomgarden, R., Yean, D., Yee, M-C.,
Cimprich, K. A. (2004) A novel protein activity mediates DNA binding of
an ATR-ATRIP complex. J.
Biol. Chem. 14, 13346-13353. [Medline]
Barr,
S. M., Leung, C. G., Chang, E. E.,
Cimprich, K. A. (2003) ATR kinase activity regulates the intranuclear
translocation of ATR and RPA following ionizing radiation. Current
Biology, 13, 1047-1051. [Medline]
Cimprich,
K. A. (2003) Fragile sites:
breaking up over a slowdown. Current
Biology, 13, R231-R233. [Medline]
Ferrell,
J. E. Jr., Cimprich, K. A. (2003)
Enforced proximity in the function of a famous scaffold. Mol
. Cell
11, 289-291. [Medline]
Costanzo,
V., Shechter, D., Lupardus, P. J.,
Cimprich, K. A., Gottesman, M., Gautier, J. (2003) An ATR and
Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA
replication. Mol. Cell
11, 203-213. [Medline]
Lupardus,
P. J. Byun, T., Yee, M-C.,
Hekmat-Nejad, M., Cimprich, K. A. (2002) A requirement for replication
in activation of the ATR-dependent DNA damage checkpoint. Genes
Dev. 16, 2327-2332. [Medline]
Post,
S., Weng, Y., Cimprich, K.A., Chen,
L.B., Xu, Y. and Lee, E. (2001) Phosphorylation of serines 635 and 645
of human Rad17 is cell cycle regulated and is required for G1/S
checkpoint activation in response to DNA damage. Proc.
Natl. Acad.
Sci. USA, 98, 13102-13107. [Medline]
Hekmat-Nejad,
M., You, Z., Yee, M-C.,
Newport, J. W., Cimprich, K. A. (2000) Xenopus ATR is a
replication-dependent chromatin binding protein required for the DNA
replication checkpoint. Current
Biology, 10, 1565-1573. [Medline]
Canman,
C. E., Lim, D-S., Cimprich, K. A.,
Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B.,
Siliciano, J. D. (1998) Activation of the ATM kinase by ionizing
radiation and phosphorylation of p53. Science,
281,
1677-1679. [Medline]
Cliby,
W.A., Roberts, C.J., Cimprich, K.A.,
Stronger, C.M., Lamb, J.R., Schreiber, S.L., Friend, H.S. (1997)
Overexpression of a kinase-inactive ATR protein causes sensitivity to
DNA damaging agents and defects in cell cycle checkpoints. EMBO
J.,
17, 159-169. [Medline]
Cimprich,
K.A., Shin, T.B., Keith, C.T., and
Schreiber, S.L. (1996) cDNA cloning and gene mapping of a candidate
human cell cycle checkpoint protein Proc.
Natl. Acad. Sci.
USA 93, 2850-2855. [Medline]
Corey,
E.J. and Cimprich, K.A. (1994) Highly
enantioselective alkynylation of aldehydes promoted by chiral
oxazaborolidines. J. Am.
Chem. Soc. 116, 3151-3152.
Corey,
E.J. and Cimprich, K.A. (1992)
Enantioselective routes to chiral benzylic thiols, sulfinic esters and
sulfonic acids illustrated by the 1-phenylethyl series. Tetrahedron
Letters 33, 4099-4102.
Corey,
E.J., Cheng, X-M., and Cimprich, K.A.
(1991) 1-Mesityl-2, 2,2-trifluoroethanol, an outstanding new controller
for catalyzed Diels-Alder reactions. Tetrahedron
Letters 32,
6839-6842.
Corey,
E.J., Cheng, X-M., Cimprich, K.A.,
and Sarshar, S. (1991) Remarkably effective and simple syntheses of
enantiomerically pure secondary carbinols from archiral ketones. Tetrahedron
Letters 32, 6835-6839.
