Sollier J, Stork, CT, Garcia-Rubio ML, Paulsen RD, Aguilera, A, Cimprich KA. (2014). Transcription-Coupled Nucleotide Excision Repair Factors Promote R-loop-Induced Genome Instability. Mol Cell. 56 (6) 777-785. [Medline]

Zeman MK, Lin JR, Freire R, Cimprich KA. (2014). DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis. J Cell Biol. 206(2): 183-197. [Medline]

Hamperl S, Cimprich KA. (2014). The contribution of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instability. DNA Repair. 19: 84-94. [Medline]

de Jesus Perez VA, Yuan K, Lyuksyutova MA, Dewey F, Orcholski ME, Shuffle EM, Mathur M, Yancy L Jr, Rojas V, Li CG, Cao A, Alastalo TP, Khazeni N, Cimprich KA, Butte AJ, Ashley E, Zamanian RT. (2014). Whole-exome sequencing reveals TopBP1 as a novel gene in idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med. 189(10): 1260-1272. [Medline]

Zeman MK, Cimprich KA. (2014). Causes and consequences of replication stress. Nat Cell Biol. 16(1): 2-9. [Medline]

Choi HJC, Lin JR, Vannier JB, Slaats GG, Kile AC, Paulsen RD, Manning DK, Beier DR, Giles RH, Boulton SJ, Cimprich KA. (2013). NEK8 Links the ATR-Regulated Replication Stress Response and S Phase CDK Activity to Renal Ciliopathies. Mol Cell. 51(4): 423-439. [Medline]

Machado LE, Pustovalova Y, Kile AC, Pozhidaeva A, Cimprich KA, Almeida FC, Bezsonova I, Korzhnev DM. (2013). PHD domain from human SHPRH. J Biomol NMR. 56(4):393-399.

Couch FB, Bansbach CE, Driscoll R, Luzwick JW, Glick GG, Bétous R, Carroll CM, Jung SY, Qin J, Cimprich KA, Cortez D. (2013). ATR phosphorylates SMARCAL1 to prevent replication fork collapse. Genes Dev. 27(14):1610-1623. [Medline]

Duursma AM, Driscoll R, Elias JE, Cimprich KA. (2013). A Role for the MRN Complex in ATR Activation via TOPBP1 Recruitment. Mol Cell. 50(1): 116–122. [Medline]

Zeman MK, Cimprich KA. (2012). Finally, polyubiquitinated PCNA gets recognized. Mol Cell. 47(3), 333-334. [Medline]

Lin JR, Zeman MK, Chen JY, Yee MC, Cimprich KA. (2011). SHPRH and HLTF act in a damage-specific manner to coordinate different forms of postreplication repair and prevent mutagenesis. Mol Cell. 42(2):237-49. [Medline]

Duursma AM, Cimprich KA. (2010). Checkpoint recovery after DNA damage: a rolling stop for CDKs. EMBO Rep. [Medline]

Van C, Yan S, Michael WM, Waga S, Cimprich KA. (2010). Continued primer synthesis at stalled replication forks contributes to checkpoint activation. J Cell Biol. 189(2):233-46. [Medline]

Driscoll R, Cimprich KA. (2009). HARPing on about the DNA damage response during replication. Genes Dev. 23(20): 2359-65. [Medline]

Paulsen RD, Soni DV, Wollman R, Hahn AT, Yee MC, Guan A, Hesley JA, Miller SC, Cromwell EF, Solow-Cordero DE, Meyer T, Cimprich KA. (2009) A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. Mol Cell. 35(2): 228-39. [Medline]

Kochaniak AB, Habuchi S, Loparo JJ, Chang DJ, Cimprich KA, Walter JC, van Oijen AM. (2009) Proliferating cell nuclear antigen uses two distinct modes to move along DNA. J Biol Chem. 284(26): 17700-10. [Medline]

Chang DJ, Cimprich KA. (2009) DNA damage tolerance: when it's OK to make mistakes. Nat Chem Biol. 5 (2): 82-90. [Medline]

Cimprich K.A., Cortez D. (2008) ATR: An essential regulator of genome integrity. Nat Rev Mol Cell Biol [Medline]

Cimprich K.A. (2007) Probing ATR activation with model DNA templates. Cell Cycle [Medline]

Paulsen, R.D., Cimprich, K.A.  (2007)  The ATR pathway:  Fine-tuning the fork..  DNA Repair  [Medline]

MacDougall, C.A., Byun, T.S., Van, C., Yee, M.C., Cimprich, K.A.  (2007)  The structural determinants of checkpoint activation.  Genes Dev  21, 898-903.  [Medline]

Lupardus, P.J., Van, C., Cimprich, K.A.  (2007)  Analyzing the ATR-mediated checkpoint using Xenopus egg extracts.  Methods  41(2), 222-231.  [Medline]  

Chang, D.J., Lupardus, P.J., Cimprich, K.A.  (2006)  Monoubiquitination of PCNA induced by stalled replication requires uncoupling of DNA polymerase and MCM helicase activities.  J Biol Chem  281(43), 32081-32088.  [Medline]

Bomgarden, R.D., Lupardus, P.J., Soni, D.V., Yee, M.C., Ford, J.M., Cimprich, K.A.  (2006)  Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase eta on ATR checkpoint signaling.  EMBO  25(11), 2605-2614.  [Medline]

Lupardus, P.J., Cimprich, K.A.  (2006)  Phosphorylation of Xenopus Rad1 and Hus1 defines a readout of ATR activation that is independent of Claspin and the Rad9 carboxy-terminus.  Mol Biol Cell, 17(4), 1559-1569.  [Medline]

Sobeck, A., Stone, S., Costanzo, V., de Graaf, B., Reuter, T., de Winter, J., Wallisch, M., Akkari, Y., Olson, S., Wang, W., Joenje, H., Christian, J.L., Lupardus, P.J., Cimprich, K.A., Gautier, J., Hoatlin, M.E.  (2006)  Fanconi anemia proteins are required to prevent accumulation of replication-associated DNA double-strand breaks.  Mol Cell Biol, 26(2), 425-437.  [Medline]

Yee, M-C., Fas, S. C., Stohlmeyer, M. M., Wandless, T. J., Cimprich, K. A.  (2005)  A cell-permeable activity-based probe for protein and lipid kinases.  J. Biol. Chem., 280, 29053-29059.  [Medline]

Byun, T. S., Pacek, M., Yee, M-C, Walter, J. C., Cimprich, K. A. (2005) Functional Uncoupling of MCM Helicase and DNA Polymerase Activities Activates the ATR-Dependent Checkpoint. Genes Dev, 19, 1040-1052. [Medline]

O'Connell, M. J. and Cimprich, K. A. (2005) G2 damage checkpoints:  what is the turn-on?.  J Cell Sci, 118, 1-6.  [Medline]

Lupardus, P. J. and Cimprich, K. A. (2004) Checkpoint adaptation: Molecular mechanisms uncovered. Cell, 117, 556-557. [Medline]

Bomgarden, R., Yean, D., Yee, M-C., Cimprich, K. A. (2004) A novel protein activity mediates DNA binding of an ATR-ATRIP complex. J. Biol. Chem. 14, 13346-13353. [Medline]

Barr, S. M., Leung, C. G., Chang, E. E., Cimprich, K. A. (2003) ATR kinase activity regulates the intranuclear translocation of ATR and RPA following ionizing radiation. Current Biology, 13, 1047-1051. [Medline]

Cimprich, K. A. (2003) Fragile sites: breaking up over a slowdown. Current Biology, 13, R231-R233. [Medline]

Ferrell, J. E. Jr., Cimprich, K. A. (2003) Enforced proximity in the function of a famous scaffold. Mol . Cell 11, 289-291. [Medline]

Costanzo, V., Shechter, D., Lupardus, P. J., Cimprich, K. A., Gottesman, M., Gautier, J. (2003) An ATR and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. Mol. Cell 11, 203-213. [Medline]

Lupardus, P. J. Byun, T., Yee, M-C., Hekmat-Nejad, M., Cimprich, K. A. (2002) A requirement for replication in activation of the ATR-dependent DNA damage checkpoint. Genes Dev. 16, 2327-2332. [Medline]

Post, S., Weng, Y., Cimprich, K.A., Chen, L.B., Xu, Y. and Lee, E. (2001) Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G1/S checkpoint activation in response to DNA damage. Proc. Natl. Acad. Sci. USA, 98, 13102-13107. [Medline]

Hekmat-Nejad, M., You, Z., Yee, M-C., Newport, J. W., Cimprich, K. A. (2000) Xenopus ATR is a replication-dependent chromatin binding protein required for the DNA replication checkpoint. Current Biology, 10, 1565-1573. [Medline]

Canman, C. E., Lim, D-S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B., Siliciano, J. D. (1998) Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science, 281, 1677-1679. [Medline]

Cliby, W.A., Roberts, C.J., Cimprich, K.A., Stronger, C.M., Lamb, J.R., Schreiber, S.L., Friend, H.S. (1997) Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA damaging agents and defects in cell cycle checkpoints. EMBO J., 17, 159-169. [Medline]

Cimprich, K.A., Shin, T.B., Keith, C.T., and Schreiber, S.L. (1996) cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein Proc. Natl. Acad. Sci. USA 93, 2850-2855. [Medline]

Corey, E.J. and Cimprich, K.A. (1994) Highly enantioselective alkynylation of aldehydes promoted by chiral oxazaborolidines. J. Am. Chem. Soc. 116, 3151-3152.

Corey, E.J. and Cimprich, K.A. (1992) Enantioselective routes to chiral benzylic thiols, sulfinic esters and sulfonic acids illustrated by the 1-phenylethyl series. Tetrahedron Letters 33, 4099-4102.

Corey, E.J., Cheng, X-M., and Cimprich, K.A. (1991) 1-Mesityl-2, 2,2-trifluoroethanol, an outstanding new controller for catalyzed Diels-Alder reactions. Tetrahedron Letters 32, 6839-6842.

Corey, E.J., Cheng, X-M., Cimprich, K.A., and Sarshar, S. (1991) Remarkably effective and simple syntheses of enantiomerically pure secondary carbinols from archiral ketones. Tetrahedron Letters 32, 6835-6839.


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